What is the origin of cell line? For example, I have cell lines from JHU cancer cells. From metastasis oral scc and laryngeal scc. They share similar characters as morphology and response to treatment. How they share similar characters although different patients? And for cell line from tongue for example, does it taken from only same patient then make many vials from it?.
When you have doubts, test the authenticity of cell lines using STR fingerprinting.
Cancer epithelial cell lines do share certain morphological and growth-factor requirements for cell proliferation in culture. Therefore, as Goodwin noted, when not sure additional investigation is critical. Further, it is important to find out the origin of all cell lines and the culture conditions to maintain their original characteristics that differentiate them from others.
Thanks I am not in doubt, it was a question from a student. He wants to understand how companies do cell lines.
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