It is utmost importance to understand the microbiome profile associated with genetic disorders. I studied the composition and function of microbiome profile associated with OSCC tissues compared with FEP controls. In disease with well established aietiology involving genetics and epigenetics factors,microbiome may or may not play a causative role. Nevertheless, they can adopt to the tumour microenviroment while modifying it. Furthermore, their metabolic pathways contribute to increase the inflammation in tumour micro environment by changing the composition to dysbiotic state.That means microbiome profile may influence the prognosis of OSCC. Thus, animal experiments are useful to study all ecological theories in any eco system such symbiosis,dysbiosis, cooperate evolution and competitive exclusion. Of course, CF associated will be able to use for therapeutic purposes (microbiomics) in the era of personalized medicine.
I would like to read all updates on this project.
Dear Scientist, I wish you all the best!
Maybe this paper is helpful:
BMC Pulm Med. 2018 May 22;18(1):87. doi: 10.1186/s12890-018-0632-6.
The lung microbiome in children with HIV-bronchiectasis: a cross-sectional pilot study.
Masekela R1,2, Vosloo S3, Venter SN3, de Beer WZ3, Green RJ4.
Thank you. This paper is really useful. I also agree with the authors, the species richness and diversity is less in HIV-bronchiectasis group due to the dysbiotic state in severe disease condition may be due to by P. aeruginosa when compared with CF lung group.Usually in disease conditions pathogen dominates over symbiotic microbes causing less species richness and diversity. In my opinion in these situations metagenomics findings corroborate conventional culture findings.
in spite of our extended, sharp and precise knowledge of the characteristic microbiote dysregulation in several diseases, we are far from studying microbiote enhancement or reparing in lung diseases.
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