Combination of cryosurgery and with Iodine-125 seeds provides a promising result for the patients with unresectable cancer, especially the patients with centrally-located tumors .
If properly applied, either cryosurgery or brachytherapy seed implant will completely ablate all tissue in the target volume subjected to complete freeze cycles or appropriate radiation dose. Both modalities are highly conformal in terms of the ability to spare healthy organs at risk while delivering a tumoricidal treatment, but seed implants have a better record for high cure rates and low complications. However, combining two locally lethal modalities in the same target would seem to place the patient at risk of all the complications of each treatment with little potential benefit. For example, three modalities are used very effectively in high risk and very high risk prostate patients. Brachytherapy treats the prostate with a 5 mm margin, external beam therapy boosts the prostate dose and treats the seminal vesicles and lymph nodes, and androgen deprivation therapy treats the prostate cancer and microscopic metastases. Attached are two papers on outcomes following tri-modality therapy in very high risk prostate patients.
Thank you Dr Wayyne for your interesting answer and refrences.
I am looking for this method in patients with advanced lung and pancreas cancers.
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