The Symmetry C18 column is packed with high-purity silica particles which are endcapped with C18 chains (the typical silanol endcapping with C18). The particle size distribution and packing process is strictly controlled to deliver a column that delivers excellent peak shape.

The Xbridge C18 is packed with BEH (bridged ethylene hybrid) particles which means that the silica is crosslinked with ethylene bridges. Also the C18 chain is bonded in a different way to the particles (trifunctionally bonded). This means that both the particle and the c18 phase is very resistant to harsh conditions (pH, temperature).

So: if you want a column that is very stable for a very long time, under harsh conditions, choose the Xbridge. If you work under normal conditions and you just want excellent chromatograms, choose the Symmetry.

Dear laurens,

Thank you so much for your answer. I appreciate

Have a nice day.

Dear Zakaria,

Mr. Laurens has already explained the difference very well, but I want to add that Xbridge columns not only preferable for its ruggedness or longevity, but also for high efficiency and symmetrical peaks.

Dear Sultan, 

Many thanks for your additional comment.

Sincerely yours.

I would like to know difference between nucles c18 and Xbridge c18 HPLC column?

Thanks 

thank you, for your answer, xbridge beh:)

Can I use Xbridge C18 (3x150mm,3.5um) column in a Acquity UPLC system?

The Symmetry C18 column is packed with high-purity silica particles which are endcapped with C18 chains (the typical silanol endcapping with C18). The particle size distribution and packing process is strictly controlled to deliver a column that delivers excellent peak shape.

The Xbridge C18 is packed with BEH (bridged ethylene hybrid) particles which means that the silica is crosslinked with ethylene bridges. Also the C18 chain is bonded in a different way to the particles (trifunctionally bonded). This means that both the particle and the c18 phase is very resistant to harsh conditions (pH, temperature).