Reading literature about mitochondria fission/fusion mechanism I came across two oposite explanations on role of phosphorylation of DRP1 in regulation of mitofission. Study of Han and colleagues 2008 reports increase in fission with increase of DRP1 phosphorylation, while two other papers: Chang and Blackstone 2007 an Cribbs and Strack 2007- observe an oposite situation: phosphorylation of DRP1 (at same residue as in Han experiment) causes inhibition of fission.
I do not have any experience in this field and would like to know whether there is any consensual mechanism worked out. Thank you in advance for your insights.
Interesting question. Wang et al. (http://www.ncbi.nlm.nih.gov/pubmed/22326220) looked into the different findings on the contribution of Drp1 S600 phosphorylation (corresponding to S637 in human Drp1 isoform 1) to mitochondrial dynamics. They conclude: "Our interpretation of these seemingly contradictory observations is that the functional consequences of serine phosphorylation of Drp1 could be highly cell-type and/or stimulus dependent."
I am looking forward to see more studies addressing the role of Drp1 S600 phosphorylation on mitochondrial fission regulation.
Cheers, Christian
Hello there,
Thank you for this question. I've been searching for the same question for the past days. Did you find a good paper explaining the answer and wether Drp1 phosphorylation results in increase or a decrease in fission?
I would highly appreciate sharing papers
Thank you
Assraa
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