I select poorly water soluble drug that I want to increase solubility by nano particle formulation by decreasing size of particle solubility is increased so I want to measure solubility practically.
Daniel Ricardo Delgado
Dear, Ravi Reddy, The apparent solubility increases with decreasing particle, however this solution may not be thermodynamically stable. The best way to determine the solubility is by the method of agitation from jar, takes approximately 10 mL of solvent, add asufficient solute to form two phases (liquid-saturated phases and solid-solid phase undissolved) you should let it equlibrio (about 3 days)- the thermodynamic stability-then determines the solubility for some analytical methodology. To increase the solubility, I recommend using cosolvents.
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