Nanoparticle surface forces are more when compared to body forces so how do drugs get entrapped in to core
If you take hollow core silica shell nanoparticles one can adsorpe drug (eg. Ibuprofen) through hydrophobic attraction. This silica is inert and the drug can be released in stomach juices. By this way one can entrape and relase the drugs in nanoparticles.
Hi ravi reddy,
first of all there are different types of nanoparticles. so, depending on the nanoparticles and their preparation methods and chemicals used their entrapment of drug differs from one type of nanoparticulate delivery to other. For example in nano vesicular preparations like niosomes and proniosomes we use various excipients like membrane stabilizers, surfactants, coating materials, alcohols etc., here the alcohol helps in increasing the drug solubility and the surfactants, coating material coats the material and increases more drug entrapment and membrane stabilizers helps to stabilize the nanoparticle membrane. so it differs from formulation to formulation depending on the excipients used and excipients are selected in according depending on the target organ, so that they can attract and become stable at that particular organ.
hope its helpful,
regards.
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