Let's take an example like my lipid-based formulation showed ~ 110mV zeta potential, I am a bit worried about the stability of formulation after keeping it in storage for a few months.
Thanks in advance.
110mV is unusually high. I would be suspicious of the validity of the measurement. What technique did you use? What was the composition of your sample?
Note, zeta potential is just one property of a system that can be used to help predict stability but other information is needed. It is a common misconception that measuring zeta potential is enough to infer stability.
Thank you for your reply. The composition was drug + lipid (glyceryl monostreate) + surfactant/cosurfactant (pluronic F127/ Tween 80). The charge of formulation was measured by photon correlation spectroscopy technique.
Unless your drug produce so high charge, lipid and used surfactants (pluronic 1127/Tween 80) does not produce so high charge. I recommend to analyse again.
Mohammad Imran : if your zeta potential is really 110mV then it would indicate a stable formulation. The number is large, and you should check if all the settings in the analysis are correct. Very large zeta values may exist for quite small charged micelles. Have you also done DLS on the sample and found the hydrodynamic size?
Ulf Nobbmann thank you for your valuable suggestion.
Yes, the mean diameter was 199 nm.
Then I would agree that 110mV is quite large. It may be a particle-particle interaction effect. This cold for example show if the viscosity quite different from water. You could share the data if you like.
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