Dear Dr. Bashier, I am sending you a few links to papers on modeling anemia. Maybe it will help you.
A mouse model for an erythropoietin-deficiency anemia https://dmm.biologists.org/content/3/11-12/763
A novel acute anemia model for pharmacological research in mice https://www.nature.com/articles/aps2009161
Characterization of an Animal Model to Study Risk Factors and New Therapies for the Cardiorenal Syndrome https://www.karger.com/Article/Fulltext/462984