What are the optimal ADME parameter values of a Small molecule Vaccine Adjuvant?

Uddipta Ghosh Dastidar @Uddipta-Ghosh-Dastidar

04 October 2024 0 534 Report

I have developed a small molecule intended to be used as a vaccine adjuvant.

What are the ideal and acceptable values of

1. LogD,

2. Human LIver Metabolism (HLM),

3. Mouse LIver Metabolism (MLM),

4. Human Plasma stability or Mouse Plasma stability for a Vaccine Adjuvant.

Are there any references?

Badges
Science method

More Uddipta Ghosh Dastidar's questions See All

Z-average size from Dynamic Light scattering can it be lower than the original probe size?

Hi everyone, Recently I have been conducting Dynamic Light scattering experiments in a micellar solution at 5 and gel at 37 degrees of Celsius with latex particles of diameter 190-500 nm. While...

01 August 2024 1,168 4 View

GSH estimation assay: What is the right choice of standard?

Hi there, My question is: What standard curves should be used while estimating Tot GSH and GSSG by kinetic method using GR enzyme mediated recyling with DTNB chromophore? Actually I am following...

01 August 2024 8,217 1 View

Intracerebroventricular (ICV) AAV inj.?

I'd like to know if anyone has got experience in intracerebroventricular (ICV) AAV inj. I am looking for a concomitant spread of the AAV including but not limited to the motor cortex and the...

12 July 2024 781 0 View

What is the maximum acceptable degradation of gain in the orthogonal plane relative to the beam scanning plane for beam steering antennas?

In research papers on beam steering antennas, while the radiation pattern for the beam scanning plane (such as the horizontal or vertical plane) is typically presented, details regarding the...

03 July 2024 8,321 0 View

What kind of surface morphology must be there for good photocatalytic activity of thin film?

If I want to increase the photocatalytic activity of a thin film sample what should be it's ideal surface morphology and parameters? All scientific answers related this are highly appreciated.

19 June 2024 6,744 0 View

Why I am getting follwing error when I tried to open .dta file in SPSS25?

>Error # 7202. Command name: GET STATA >Input dictionary read error. >Execution of this command stops. Cross Product Matrices are not supported

19 June 2024 5,423 0 View

Which deposition technique is better (Spin Coating/Dip Coating) for making Ni doped ZnO thin film for better photocatalytic activity?

If I want to improve the photocatalytic activity of Ni doped ZnO thin film then which would be the better deposition process for thin film Spin Coating or Dip Coating?

18 June 2024 7,678 2 View

What are the possible parameters needed to be tuned for better photocatalytic activity of thin film?

If I want to enhance the photocatalytic activity of Ni doped ZnO thin film. For this what are the parameters I need to tune and how? Related this all scientific answers/explanations are highly...

16 June 2024 4,533 1 View

Curing of Novolak resin with hexamine develops yellow color. I believe it is due to azo linkage -C-N=N- C- What is the reaction mechanism?

Also, I will appreciate whole curing mechanism of Novolak with Hexamine

14 June 2024 9,908 0 View

How are cancerous cell lines generated in 1900s sold today have the same genetic profile?

From the definition of cell line, they are indefinitely propagated/subcultured. However, in practice beyond a certain passage number, they are said to loose characteristic gene profile, for e.g....

10 June 2024 6,890 1 View

What are the steps of formulating a herbal extract into a sheep/goat drench?

I am working on natural remedies for de-worming in small ruminant livestocks. Part of my project involves formulation of drench-type product, which I have not much experience in. My experience is...

30 July 2024 9,806 1 View

Has the Affordable Connectivity Program Helped You/Your Community? And Would Bulk Tablets on a Similar Program Help Your Business?

Do You Believe VP Harris Would Show Empathy to Tech Companies in Her Administration as POTUS? I ask in light of the fact that, the ACP was not re-funded this round. So many and businesses need...

24 July 2024 4,732 3 View

How to prepare bacterial conditioned media to study the effect of bacterial secretome?

I would like to investigate the effect of bacterial secretome on cancer cells. How do you prepare conditioned media from bacteria?? conditions- time points - media I am looking for the best way...

17 July 2024 3,785 9 View

Is the protecting group boc of the amino group stable at 37°C?

I have a small molecule reagent with a boc-protected amino group. Now the reaction needs to be reacted at 37°C for 30 h. Is this protection group stable?

12 July 2024 3,745 2 View

Can someone please explain to me what power law statistics mean in single molecule fluorescence blinking ?

I am a beginner in this field. While I am reading papers and the understanding is getting better. However can someone explain in easy and simple words. Really thankful !

08 July 2024 8,337 5 View

In silico techniques for identification of inhibitor/activator/substrate activity?

Hello dear researchers, I would like to know about available in silico tests that could predict the activity of ligands (small molecules) against the target protein. I have performed docking...

08 July 2024 4,724 4 View

How is the preparation to obtain secondary metabolic extracts?

Hi everyone! I am working with bacteria and fungal collected from marine sediments. I would to know the methodology since the preparation of biomass until the extraction and stored of secondary...

03 July 2024 6,177 3 View

Where can I find my citations for my published papers?

1- M.M.M. Ahmed, F.M. El Hag, F.S. Wahab, S.F. Salih (2001). Feeding strategies during dry summer for lactating desert goats in a rainfed area under tropical conditions. Small Ruminant Research 39...

18 June 2024 552 5 View

Is there an HSQC sequnce suitable for 13C labelled small molecules?

I work in glycobiology and one of my duties is synthesize short oligosaccharide with, at least, one sugar universally 13C-labelled. Is there any sequence that can help me with characterization,...

28 May 2024 8,039 0 View

Is there any sequence that needs to be added when synthesizing and cloning shRNA?

To create a cell line overexpressing a specific microRNA, I'm planning to synthesize and clone the shRNA sequence into a vector. Would it be sufficient to add only the termination sequence (TTTTT)...

27 May 2024 4,206 0 View