Dear Shuai Peng, I think if it is not in an acidic medium, protecting boc thermal stability is favored, because deprotection requires temperatures far above 37°C. Please have a look at the links below. My Regards

https://doi.org/10.1021/acs.oprd.3c00498

10.1016/S0040-4020(02)00131-X

N-t-Butyloxycarbonyl group is progressively labile with the increase of the acidity (both, Lewis and Brønsted) of the reaction media. To keep the Boc protecting group intact, one should make sure that the reaction is carried out under basic conditions regardless of temperature of the medium.