I found the chemical structure or formula of both are same even CAS No. But I want to know why both are different and why ?
The most apparent difference is the proprietary name (Trade name). You can find more trade names here https://en.wikipedia.org/wiki/Poloxamer_407.
However, as the products come from different sources and given the products are not a single chemical entity, but rather mixtures of similar molecular species, there might be slight differences in their physico-chemical properties (HLB, CMC, you name) as well. In most cases, the products should be interchangeable, yet the best way to verify the interchangeability is to check.
Another important aspect is the grade of the product, such as industrial, cosmetic, Pharmacopoeial, etc. In fact the practical difference between different grades might exceed that between different brands of the same grade. The grades differ in the contents of impurities, such as heavy metals, water, and coloured substances.
One particularly important parameter is peroxide content as these may destroy the products you intend to solubilise. Pluronic (and in fact most any non-ionic surfactant, such as Tween) does contain long polyethylene glycol chains, which are prone to oxidising effect of air, yielding peroxide groups. Thus if your product is prone to oxidative decomposition or inactivation, the product of choice would peroxide free grade.
The most apparent difference is the proprietary name (Trade name). You can find more trade names here https://en.wikipedia.org/wiki/Poloxamer_407.
However, as the products come from different sources and given the products are not a single chemical entity, but rather mixtures of similar molecular species, there might be slight differences in their physico-chemical properties (HLB, CMC, you name) as well. In most cases, the products should be interchangeable, yet the best way to verify the interchangeability is to check.
Another important aspect is the grade of the product, such as industrial, cosmetic, Pharmacopoeial, etc. In fact the practical difference between different grades might exceed that between different brands of the same grade. The grades differ in the contents of impurities, such as heavy metals, water, and coloured substances.
One particularly important parameter is peroxide content as these may destroy the products you intend to solubilise. Pluronic (and in fact most any non-ionic surfactant, such as Tween) does contain long polyethylene glycol chains, which are prone to oxidising effect of air, yielding peroxide groups. Thus if your product is prone to oxidative decomposition or inactivation, the product of choice would peroxide free grade.
It's the same!
Synonyms of Poloxamer are Lutrol; Monolan; Pluronic; poloxalkol; poloxamera; polyethylene–propylene glycol copolymer; polyoxyethylene–polyoxypropylene copolymer; Supronic; and Synperonic.
The difference in conformations can play an important role in the reactivity of compounds.
Its the same
Pluronic F127 is Brand name & Poloxamer 407 is a generic name
we used poloxamer 407 and pluronic 127 puchased from sigma. we prepared nanoparticles of A using poloxamer 407 and nanoparticles of materials B using pluronic 127, A and B are completely different drug molecules. is it acceptable to mentioned throughout the manuscript any one name as poloxamer 407 or pluronic 127. OR we need to mention both separately. Thank you
Very good question. Poloxamer 407 is an official chemical (IUPAC) name, associated with CAS Number. Thus, mentioning Poloxamer 407 in the bulk of the text would be OK.
No need to distinguish between the two except in Methods/Supplementary Information.
Under Methods (or in Supplementary Information, whatever your journal prefers) you would better state something like "nanoparticles of compound A were prepared using Poloxamer 407 (Sigma, catalogue number)", and "nanoparticles of compound B were prepared using Pluronic 127 (Sigma, catalogue number)".
- Badges
- Science topic
- Similar topics
- Chemistry
- Nanotechnology
- Nanostructured Materials
- Nanoparticles