Hi,

Regarding SLNP, a description appeared in a recent review article (see attached picture), says:

Solid lipid nanoparticles (SLN), on the other hand, are a recently-developed

nanocarrier (technology) utilized as an alternative to the existing drug delivery technologies including polymeric nanocarriers, emulsions and liposomes. They are a new generation of submicron-sized lipidic carriers in which the liquid lipid (oil) has been substituted by a solid lipid, i.e., the lipid particle matrix being

solid at room temperature, as well as body temperature [5 ]. Some of the solid lipids used in the preparation of SLN include triglycerides, emulsifying wax, cetyl alcohol, carnauba wax, beeswax, cholesterol and cholesterol butyrate. The underlying mechanism for the formation of the lipid vesicles is the hydrophilic–hydrophobic interactions and van der Waals forces between phospholipids and water molecules. There are a number of review articles describing the preparation methods of lipid-based vesicles, which readers are referred to for a broader coverage [1 ,2 ,5 ,8 ].

Source:

Danaei, M., Dehghankhold, M., Ataei, S., Hasanzadeh Davarani, F., Javanmard, R., Dokhani, A., Khorasani, S. and Mozafari, M.R., 2018. Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics, 10(2), p.57.

Thank you for sharing Mozafari.

Hi, please you can go through these papers....

Thank you Slavomira Doktorovova.

Dear Raj Kumar

Prof. Müller is a pioneer in the field of lipid nanoparticles (SLNs and NLCs). But I also recommend my professor’s researches (Prof. Soliman Mohammadi Samani and his team) in this field which have been written in details as numerous review and original research articles.