Dear fellow researchers,
I have data regarding frequencies and haplotype patterns of several STR markers among a cohort of patients diagnosed with a specific genetic disease.
Would it make sense to try to compare the frequency of each allele observed for each of the markers between the population of normals (unaffected people for whom no disease-causing mutations have been found) versus the affected groups with known deleterious mutations?
I tried to look for convincing evidence regarding the "founder effect" but have not been successful so far.
How would you suggest me to report the data?
What statistical analyses would be meaningful to perform?
Eagerly look forward to your reply.
Best wishes,
Negar