We know that epigenetic factors are denoted by alterations in DNA methylation, histone modification abd transcription of regulatory non coding RNA such as microRNAd but are there additional epigenetic changes that take place that do NOT involve these mechanisms?
The mechanisms of epigenetic changes, regardless what do you mean as 'epigenetic' (different notions exist), are highly diverse. Any process involved in regulation of gene expression or gene-procuct functioning can potentially lead to such changes. In particular, at least 10 different mechanisms are shown to produce epigenetic inheritance. For a reviews, see
https://doi.org/10.1111/brv.12429
- 10.1134/S2079086416040071
Also take into consideration the nuclear sub-architecture itself as a factor.
Thank you Mohamed. Are you aware of the effects of aging on this factor?
Chromossone conformation/architecture.
It might help Article Mammalian Epigenetic Mechanisms
Nucleosome remodeling and X-inactivation/X-upregulation are a few other examples that might influence gene expression. I have recently addressed the epigenetic mechanisms involved in the pathogenesis of COVID-19. I'd appreciate your comments.
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