I want to try using growth factors as a stimulus and enhancer in combination with many reconstructive maneuvers as menical repair cartilage repair or even drilling of an ulcer ,?!
Anyone has experiences?!
not a bad idea, but it is better you do not apply these factors blindly, have through knowledge of literature about growth factors affecting repair of or growth of chondrocytes. One factor I will recommend you is Fgf2 since I found in rat cartilage transplants indirectly, may help cartilage repair since MSCs expose do FGF2 make better cartilage in vitro and transplant better in r,a knee (please see my poster on my researchgate, paper in progress) Another factor you may try kartogenin (Science paper few years ago). Good luck
Nice to see this book:
My major concern is that hugh number of doctors are doing these kind of injections like injection of hyaluronic acid and platelet plasma an similar products in knee, doctors are making fraudulent way of making money without paying attention that they are severely damaging knee synovial membrane by repeated injections and thus turning osteoarthritis (so called repair) into inflammatory synovial membrane and thus giving birth to another trouble of rheumatic arthritis. In my opinion all these injections including stem cells in knee is a fraudulent bussiness so far. At the end of the day patients end up knee or hip replacement therapy which is better in majority of patients.
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