A rare silent C538T polymorphism was detected 33 bp downstream of the translation stop codon (TGA). A common polymorphism A19G was identified in the untranslated exon 1. This polymorphism was not associated with traits of obesity, frequencies were similar between 64 normal weight and 141 obese Finns.in case introduces 2 rare mutations associated with low serum leptin concentrations.

Dear Dr. Ahmed my question is why exon 1 in leptin gene is untranslated my think is because the alternaive splicing and the potent gene is alternatively spliced thank you for your response

Ismail