My liposome is a non-phospholipid liposome (sterosome) composed of palmitic acid and cholesterol, 20mg of palmitic acid and 70mg of cholesterol.
After a month of storage in a refrigerator at 4 degrees Celsius, the particle size increased from about 140 nm to 180 nm. Although the increase in particle size was not exaggerated due to cholesterol, it still increased. I would like to ask what the possible reason is ?
I know it may be sedimentation or self-aggregation, but my zeta potential is about -48mV.... I still can’t think of any other possible reasons. Since saturated fatty acids are not easily oxidized, could you please tell me what other possible reasons there are? I hope there is some literature support.
Thank you.
I-Hsuan Shih
Your liposomes are formed through water-mediated hydrophobic interactions. We discovered that hydrophobic interactions depend on the energy of thermal fluctuations of water molecules, which depend on temperature, and quantum fluctuations of water molecules, which depend on pressure. As you can see, the size of your liposomes depends on temperature, that is, thermal fluctuations. The two energy contributions of intermolecular interactions compete with each other. A new theory of this phenomenon can be read in the articles
Article Relationship between Classical and Quantum Mechanics in Mice...
Preprint Nuclear quantum effect in aqueous micellar surfactant solutions
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