The specificity of antibody of GABAB receptor subunit 2?

04 December 2024 1 2K Report

We recently plan to label GABAB receptor subunit 2 (GB2) using IHC and IF, has anyone used this antibody before: (Anti-GABA B Receptor 2/GABBR2 antibody (ab52248) | Abcam)? How about the specificity of this antibody? I would greatly appreciate it if anyone could provide some information. I have attached the paper that used this antibody. Thank you very much.

Samuel Davis

That antibody which you mention is polyclonal, if you are concerned about specificity you would be better going with a monoclonal antibody such as Abcam Ab181736 (https://www.abcam.com/en-us/products/primary-antibodies/gaba-b-receptor-2-gabbr2-antibody-5g7f7-ab181736#), although obviously you will have to use one that is reactive to the species that your samples are from.

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