The HPV infections are very prevalent so many times HPV might be rather just a side finding in cervical cancer than the causing agent. Is it possible? (As it is well-known, cervical cancer can develop without HPV infection.)
This is not possible, there can be no cervical cancer without hpv infection and hpv is the necessary cause.
Dear Priyanka Singh,
Thank you for your answer.
According to Khorasanizadeh F et al, "The prevalence of HPV infection was 76% in cervical cancer patients " (1)
Matsumoto K, Yoshikawa H.published: "Infection with a high-risk human papillomavirus (HPV) is established as a major risk factor for cervical cancer." " However, only a small fraction of infected women develop CIN 3 or invasive cervical cancer, suggesting the involvement of additional cofactors in cervical carcinogenesis. (2)
Do you accept their results?
1.)Epidemiology of cervical cancer and human papilloma virus infection among Iranian women - analyses of national data and systematic review of the literature.
Khorasanizadeh F, Hassanloo J, Khaksar N, Mohammad Taheri S, Marzaban M, H Rashidi B, Akbari Sari A, Zendehdel K.
Gynecol Oncol. 2013 Feb;128(2):277-81. doi: 10.1016/j.ygyno.2012.11.032. Epub 2012 Nov 28. Review.
PMID: 23200918
2.) Human papillomavirus infection and the risk of cervical cancer in Japan.
Matsumoto K, Yoshikawa H.
J Obstet Gynaecol Res. 2013 Jan;39(1):7-17. doi: 10.1111/j.1447-0756.2012.01977.x. Epub 2012 Aug 26. Review.
PMID: 22925027
HPV is always the cause of cervical cancer. A woman may have cancer but no longer have an active HPV infection. Many women (and men) have HPV but only a few develop cancer; however, all women who develop cervical cancer had an HPV infection (originally) which caused it.
Read: The causal relation between human papillomavirus and cervical cancer, Bosch et al. and HPV in the etiology of human cancer, Munoz et al. You can search for both on Google scholar and they are freely available on line to read.
The PUBMED contains more than 15,000 publications regarding cervical cancer and HPV infection.The human papillomavirus (HPV) is the main cause of cervical cancer according to the Centers for Disease Control and Prevention. The research in this field is continuous.
With all reaserches made in last decade is difficult today belive that the cervical cancer haven't in HPV the conditio sine qua non and the main position in the etiology of this cancer.
The method of carcinogenesis requires the genomic integration of HPV DNA into the cervical cells. The E6 and E7 proteins bind to and block the actions of the p53 and RB genes which are normally tumour suppressive. This is an an example of one of the few times an epidemiological observation is confirmed by an understanding of the cause of the cancer.
Recently other factors like female genital schistosomiasis are considered for cervical cancer.
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