Although, Selenium (Se) being an essential cofactor and also acting as an antioxidant in human body (maybe some other medical benefits in conditions such as Cancer, HIV, Crohn’s disease etc). However, in medical terminology largely there is no-point recommending Se as a “supplement”, because the tiny concentrations humans require, we can get it from food only according to Recommended Dietary Allowance (RDA).
Question? If it’s a known toxic element, why investigators still encourage studies using Se nanoparticles in drug delivery? Recently, there is an increasing surge of using Se nanoparticles. Unfortunately, understanding and preventing risk often has a low priority in the competitive world of research funding and embracing a fixed idea is one of the main dangers in the evolution of any scientific discipline.
I think its toxicity making it more important to researcher which could be positively utilized. But Post treatment elimination from body and its side effect are of concern.
Dear Mr. Shiekh,
Yes Se is toxic but Se nanoparticles at nutritional level (small amount) have been found to be non toxic. Many researches have been concluded regarding the toxicity of Se and its dosage.
For example: See this reference
http://www.sciencedirect.com/science/article/pii/S002432051400736X
Being antioxidants these nanoparticles are suitable in food supplements but obviously marking your point, in an appropriate amount below the toxicity level.
http://www.sciencedirect.com/science/article/pii/S002432051400736X
Everything is toxic - water is dangerous by inhalation. It all depends on the level- concentration and time of
Alan F Rawle is correct. Every chemical is toxic. You can make it therapeutic agent by adjusting dose, making it targeted and ensuring elimination as also indicated by Qasim.
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