As we know, pyocyanin is a redox active virulence factor of PA. It is a highly diffusable compound, but does it enter blood circulation from the site of infection?
It may it is highly diffusible and if the patient survives long enough. The patient may suffocate due to poor lung function from chronic lung infection and worse lung function by lower expiratory volume. It may only be possible in acute infection because biofilm infection may not produce as much as 100uM needed for the blue tinge of the sputum.