Kindly confirm: Can we take PTZ (Pentylenetetrazole) model as model of Status Epilepticus and clinically co-relate with human MTLE its findings ?
If we want to study acute changes of epileptogenesis, can we use kindled model of epilepsy (PTZ) ?
Apostolos Mikroulis
Hello, bit late, but yes, it is one of the models for TLE, and yes, kindling is what you would do with all these models for epileptogenesis studies.
It is causing less direct damage to the tissue than the more common kainate model, but its dose threshold varies a bit more between animals (also, age is critical : only usable after 2-3 weeks of age in rodents).
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