Is human preproinsulin molecule a good example for studying how amino acid sequences are configured according to their numbering proposed in the article "Numbering of the twenty proteinogenic amino acids"?
Preprint Numbering of the twenty proteinogenic amino acids
The amino acid sequence of the 110-amino acid preproinsulin, the initial product of the translation of insulin mRNA, is in close dependence with the numbering of the twenty proteinogenic amino acids.
Preprint Preproinsulin molecule and numbering of the twenty proteinog...
Given there are >20 proteinogenic amino acids outside eukaryota (>26) and that tRNAs facilitate the link between codon and amino acid translated which can be species specific, I would interpret these manuscripts with caution. Especially since different species show codon bias and that the numbering system in these papers is heavily influenced by charge and hydrophobicity.
Robert Adolf Brinzer , as is visible in this synthesis, this does not only concern the hydrophobicity of AAs but criteria that are very different from each other.
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