Please enlist here some troubleshooting tips and practical issues regarding Mycobacterium tuberculosis, M.leprae, NTM and other acid-fast organisms handling, detection and difficulties faced while dealing with them.
1. It is very difficult and time consuming to grow any Mycobacteria in artificial growth media.
2.No guaranteed vaccine is developed. Still the age-old BCG vaccine is in the field, activity of which is is not guaranteed.
3.In the third world countries, the malnourished people living in the dirty environment are the main sufferers. Medicines can not work to control T.B. effectively as an alternative of proper environment and proper nutrition.
4.Genetics play a strong role for development of Leprosy.
5.Among immuno-compromised patients, development of T.B. is very common. Medicine of T.B. is having a limited role among them.
6. M.bovis may also cause human T.B.
7. Irregular and incomplete therapy is the main reason for resistant T.B. development.
So, like many other diseases, prevention is far more important tan cure for Myobacteral diseases also.
Worldwide, the occurrence of nontuberculous mycobacteria is rising. Current recommendations for care, while of undoubted importance, are restricted by these limitations. The majority of currently prescribed treatment regimens include extended use of multiple antimicrobial agents associated with multiple possible adverse effects that are self limiting and permanent, including irreversible deterioration of hearing, vision and kidney function.Many expert views, case series, and few randomized controlled trials form the evidence base for clinical management. However, little is understood about how care affects the overall health status of an individual patient.
I suggest this article for more info: Article Managing Pulmonary Nontuberculous Mycobacterial Infection. T...