Is acrylamide classified as human mutagen or carcinogen? is there any difference between mutagen and carcinogen?
1. part -Is acrylamide classified as human mutagen or carcinogen?
A review of mechanisms of acrylamide carcinogenicity - https://academic.oup.com/carcin/article/28/3/519/2476708/A-review-of-mechanisms-of-acrylamide
Acrylamide carcinogenicity. - http://pubs.acs.org/doi/abs/10.1021/jf8004492
Food controversies -Acrylamide- http://www.cancerresearchuk.org/about-cancer/causes-of-cancer/diet-and-cancer/food-controversies#food_controversies0
Acrylamide and Cancer Risk - https://www.cancer.org/cancer/cancer-causes/acrylamide.html
For understanding of known information about acrylamide-https://pubchem.ncbi.nlm.nih.gov/compound/acrylamide#section=Top
2. part - is there any difference between mutagen and carcinogen?
A mutagen is anything which changes the DNA with a cell, resulting in a mutated form of that cell if/when it replicates. A carcinogen is anything which alters a cell in such a way that it does not undergo normal programmed cell death as quickly as it multiplies via mitosis, and therefore replicates in an uncontrolled fashion.
Most mutagens are also carcinogens, and most carcinogens are also mutagenic, but there are some non-carcinogenic mutagens (damaging DNA but not triggering unusually long cell life) and some non-mutagenic carcinogens (altering a cell's metabolism but not altering DNA). [Tim Hofstetter, Medically autodidactical
Written 19 Dec 2014] https://www.quora.com/What-exactly-is-the-difference-between-a-mutagen-and-a-carcinogen
I hope you will find the answer..
Acrylamide was shown to be a neurotoxicant, reproductive toxicant, and carcinogen in different animal species. But, up to now, only the neurotoxic effects were observed in humans and at high levels of exposure in occupational settings. Acrylamide is currently classified by IARC as a Group 2A (probable carcinogen).
A mutagen induces heritable changes in cells or organisms. A carcinogen induces unregulated growth processes in cells or tissues of multicellular organisms, leading to the disease called cancer. Although mutagen and carcinogen are not synonymous terms, the ability of a substance to induce mutations and its ability to induce cancer are strongly correlated. Nevertheless, some carcinogens are non-genotoxic and acts epigenetically.
http://www.cancerresearchuk.org/about-cancer/causes-of-cancer/diet-and-cancer/food-controversies#food_controversies0
Mutagen is anything which has the potential of generating a mutation. Mutations are not always a bad thing. Species evolving better is a result of mutations occurring through various generations.
Carcinogen
Carcinogen is anything which has the potential of generating cancer. Cancer is a phenomenon which occurs as a result of mutated cell cycle processes. A cell ideally has a life cycle, and after sometime it faces a cell death. If the cell cycle is mutated or related processes are changed due to some factor cells may live longer and multiply rapidly without proper functioning. This is very harmful for the normal cells and normal biological processes. Carcinogens can induce such cell behavior inside one’s body.
• Mutagens cause mutations in the genetic material but carcinogens cause cancer.
• Most mutagens can be carcinogens and most carcinogens can be mutagens but, it is not necessary for one substance to be both.
For more details , you can visit the following link:
http://www.differencebetween.com/difference-between-mutagen-and-vs-carcinogen/
Dr. Aalaa,
A mutagen is a substance or agent that induces heritable change in cells or organisms. ... Although mutagen and carcinogen are not synonymous terms, the ability of a substance to induce mutations and its ability to induce cancer are strongly correlated
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