I have been searching for SNPs in miRNA genes (formulated panel of 65) in a designated breast cancer population by iPLEX/MALDI-TOF-MS. But after that just got stuck into and couldn't go further.
Expression analysis was suggested by someone, but all I need is some strong, supportive strategy to back my genotype data.
All I need is a follow-up strategy.
thanks in advance.
NB: I am just at the very beginning of my PhD career on Cancer Genomics. So, need some expert opinion to walk through the path.
SNPs which occur at miRNA-related regions it may change in phenotype. still there is need to know about the evolution of miRNAs after SNP variation, there is possibility to perform genome-wide scan of miRNA-related SNPs, need to analyze their effects on the stability of miRNAs structure and the alteration of target spectrum in plants for more information refer following link.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883715/pdf/12284_2012_Article_46.pdf
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