Hi,
I am working on developing an MRI based imaging method for measuring/detecting creatine recovery rate in creatine kinase (CK) reaction post plantar flexion exercise.
It's 2D variant, with single slice coverage of 10-20 mm thickness, has already been developed. Whereas I am developing it's 3D varaint with
with multi slice coverage (4-5 mm thick slices), while still keeping the same temporal resolution of 30 seconds. So, using my method I can probe multiple slice. This allow us sufficient resolution in plane (~1mm) and also along the muscle length (4-5 mm resolution with ~30 mm coverage).
Since only 3D method can probe the intramuscular heterogeneity in CK kinetic along the muscle length, I am very interested in knowing some skeletal muscle disorders where the assessment of intramuscular heterogeneity along the muscle length may be valuable. This will make my work, allowing multi-slice coverage, more significant. I would very much appreciate some inputs.
One of such disorders could be Duchenne muscular dystrophy.
Regards,
Dushyant
Dear Mr. Kumar.
I am not sure but may be you finds some relevant inputs from this study
Multi-slice MRI reveals heterogeneity in disease distribution along the length of muscle in Duchenne muscular dystrophy
Acta Myologica • 2017; XXXVI: p. 151-162
Regards
Thanks Somesh. I already knew about that paper, hence, there was a mention of Duchenne muscular dystrophy in my original post.
I do not think that most pts with MD have this feature quantified, as a general rule. Would it not require extensive biopsy to validate the imaging methods? What exactly dyu mean by intramuscular heterogeniety? Genetics heterogeneity?
Dear Prof. Andersson, Apologies for the delay in responding. Somehow I did notice any notification for your reply from research gate. Previously, our lab has developed a method to measure recovery kinetic of creatine following plantor flexion exercise. That method could only image 2D slice and hence, could distinguish inter-muscular difference between say lateral gastroc, medial gastroc etc from a single inplane image. I extended the method to enable mapping along the muscular length i.e. my method is 3D. So, I can measure difference between various muscle groups as well as if there is an abnormality within same muscle. I am writing "introduction" of my paper and would like to demonstrate the significance of my work in various creatine kinease disorders, which are non systemic and hence, the ability to scan multiple slice may bring unique information.
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