Osmoregulatory responses mitigate the passive adjustments in cell structure and the growth inhibition that may ensue. In fungi, the HOG pathway through MAPK is linked to both, osmosensing and pathogenicity. however, I couldn't find any relevant publications for a similar mechanism in bacteria that can link the change in regional osmolarity and the pathogenicty / dysbiosis. I'm interested on the premise that an overgrowth of certain species / subpopulation can perpetrate dysbiosis through altering the regional medium osmolarity, independent of other inter-cellular signaling.
Hello, the mediate or direct osmoregulatory responses that allow cells to survive osmotic changes and extremes. Bacterial osmosensing transporters sense high external osmotic pressure and respond by mediating organic osmolyte uptake, hence cellular rehydration.
I think the direct evidence of dysbiosis through altering the regional medium is bacterial antogonism. In some cases it can be connected with critical osmolarity change due to overgrow.
Thank you for your input; kindly ignore my lengthy question, but my query in short is: do bacteria posses a linked osmosensing-pathogenicty mechanism as in fungi? In other words, if i selectively altered the media osmolality in a mixed organisms culture, can i expect a selective changed in overgrowth !
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