Usually calcitriol is given to CKD patients or patients suffering from DM type-II. And for others it is suggested to use Cholecalciferol or Vitamin D3 as supplementation. Physicians also reported that long term calcitriol intake reduces some sort of antioxidant production as the dependency grows gradually for calcitriol and body cannot able to convert cholecalciferol into calcitriol as it was before.
Christine Houghton
I would have expected the opposite because Calcitriol is an Nrf2 activator and this transcription factor is responsible for upregulating expression of the antioxidant enzymes as well as the genes coding for glutathione synthesis.
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