Some rare references nowadays focus on autoimmune neurologic diseases triggered by some vaccines such as flu vaccine . I want to estimate incidence rate of this subject annually... Can anyone help me?
Dear Ramin
There are some evidences of autoimmune reaction after vaccination, and some researches showed its possible role in initiating the autoimmune response. But based on the exact mechanisms and pathology of MS there is no any relationship and similarity between Flu virus antigens and Myelin Basic Protein as objective protein in MS! EBV and Clamydia infections are mostly possible involved agents in triggering the autoimmune reactivity in multiple sclerosis! Meanwhile even with less posibility to observe the chance of this side effect long time is needed and as far as I know there is no any follow up studies to monitor the fate of vaccinated people. Hope it contains some information.
https://www.cdc.gov/vaccinesafety/concerns/history/narcolepsy-flu.html The Pandemrix case is the one I am aware of that showed a link. The cases of narcolepsy were less than in people who got infected with that H1N1 strain of influenza. But they were higher than in people who got neither.
There is no evidence I know of for a link to multiple sclerosis.
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More generally, autoimmunity to vaccines is very rare, with zero epidemiological evidence aside from Pandemrix.
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2011.02467.x/full
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Since vaccinations that are not live virus induce a much milder immune response than any real disease does, autoimmune induction is exceedingly unlikely. Autoimmune induction
Live virus can induce autoimmunity, but this should be in severe disease, not the attenuated viruses used in vaccines.
Article Virus infection, antiviral immunity, and autoimmunity
There is a class of adjuvant that is used in animal studies for the purpose of inducing autoimmune disorders. It's possible to do it fairly reliably by triggering an extreme immune response.
Dear Brian, thanks a lot for your complete and useful answer... I wish you answer my other related questions like this one and follow my questions and articles
Ok. Answering depends on having the time and if I have looked into that topic before as a rule. I do have an interest in certain traditional medicine approaches to immune system issues, which you seem to have also. Helminths for instance. There's not a lot of good work on use of leeches, but some interesting anecdotes for various autoimmune disorders.
However, since every lymph node is innervated, and interfering with the vagus nerve which is the probable route for signalling, has apparently cured arthritis, and at least one group of people has shown ability to learn to control their response to endotoxin as a side effect of extraordinary cold tolerance training, the neuro-immune effect may be a large part of that. Not saying it is, but it could be. (I prefer neuro-immune to "placebo" in that area because I think placebo has connotations that aren't accurate.)
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