Dear All,
I am studying the mechanism of a protein localized in the mitochondria of liver in a mice knocked out for my specific protein. The liver has increased lipid droplets in aged mice. Also my protein was previously shown to involve in positive lipid metabolism. In this context, to understand its mechanism followed by other experiments, I hypothesize that B Oxidation could be increased in those mice. However, I am not sure if it fit with the observation that those mice also develop fatty liver upon aging?
Is it possible and making sense. Or my reasoning is wrong?
Any suggestion, criticism will be really helpful
It depends of the equilibrium of three liver metabolic processes: De Novo lipid synthesis, VLDL formation and export and fatty acid oxidation. Even with increased fatty acid oxidation, an excess of DNL and a reduction in VLDL export can produce fatty liver.
Dear Juan Carlos,
Thank you very much for your answer.
In increased lipogenesis situtation and malonyl coa increase will it not inhibit fatty acid oxidation ?
Yes, of course, but finally what it matters is the final result of the three processes together.
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