It looks like azole transporters are similar in many fungi, saprophytes, plant and human pathogens. Many of hte azole transporters have homology to CDR1, like BcatrD (and a bit B) from Botrytis and AtrG (and B) from A. nidulans. Are all other 19 transporters used in this study falling in other clades?
Article The cdr1B efflux transporter is associated with Non-cyp51a-m...
My opinion for what its worth is that transporters have been "rewired" from organism to organism. For example the primary cdr1 orthologue in A. fumigatus is not an azole efflux transporter. Looking at our RNA seq data we see many MFS and ABC transporters up or down regulated in repsonse to azole - not many are related to azole efflux. Similarly a sizeable proportion of the MFS/ABC gene complement is located in secondary metabolism gene clusters and is likely to be releated to specific efflux of the4 relevant metabolites.
So I think that although most transporters can be assigned to clades it may be misleading to assume that each clade transports structurally related compounds.
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