Is there a substance that if applied transdermally, would induce igf-1 proliferation or release?
Insulin-like growth factor-1 (IGF-1) and its receptor (IGF-1R) are required for cell proliferation in vitro, raising the possibility that an autocrine IGF-1-IGF-1R system may be present in vivo and become activated in the viable ventricular myocytes shortly after infarction.The insulin-like growth factors (IGFs) are a family of mitogenic proteins involved in the regulation of cell growth and differentiation. Increased KCC3 and KCC4 abundances contribute to IGF-1-enhanced KCC activity.( electroneutral K-Cl cotransport (KCC)
I am sorry that I cannot tell exactly the name of compound which up-regulates IGF-1, but you have to bear in mid that constitutive or even transiently hyperactive IGF-1-IGF-1-R-mediated signal induces the senescence or cell cycle arrest in a paradoxical manner (Shimizu T et al. Cancer Res. 2014 Nov 15;74(22):6531-41. doi: 10.1158/0008-5472.CAN-14-0914).
- Badges
- Science topic
- Similar topics
- Computer Communications (Networks)
- Simulators