Is there a drug or drug class that could be reasonably expected to increase mutation rates in invitro cell populations?

02 March 2015 1 3K Report

i.e. is there a type of drug that when given to cell population, would make them more likely to mutate with the addition of a DSB or SSB (zinc finger, crisper, nicks etc)? thanks

-James

Alessandro Donada

There is a couple of brand new papers that could address your question:

"Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining" Maruyama T et Al. doi:10.1038/nbt.3190

"Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells" Yu C et Al. http://dx.doi.org/10.1016/j.stem.2015.01.003

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