Transplanted human melanocytes
and metastatic melanoma cells into zebrafish blastula-stage
embryos showed that these cells could survive and
participate in embryo development without forming tumors.
The melanoma cells lost their tumorigenic phenotype(1) .Similiarly Zhou et al. show that the embryonic stem cell-conditioned medium contains factors that inhibit cancer cell growth and tumorigenicity in vitro and in vivo.
All these examples indicate that the embryo microenvironment
is able to affect cancer cell and change their phenotypes.
1.Lee M, Seftor E A, Bonde G, Cornell R A and Hendrix M
J 2005 The fate of human malignant melanoma cells
transplanted into zebrafish embryos: assessment of
migration and cell division in the absence of tumor
formation Dev. Dyn. 233 1560–70
2.S Zhou, M Abdouh, V Arena, M Arena, GO Arena. Reprogramming Malignant Cancer Cells toward a Benign Phenotype following Exposure to Human Embryonic Stem Cell Microenvironment
- PloS one, 2017 -
I guess the question that needs o be answered is what metabolites in the embryonic stem cell microenvironment are are responsible for the malignant to benign transition and them test each individually and in combination to look for potential therapeutic synergies.
The cross talk may have non-chemical basis as well. The details could be researched and explored.
Best,
Mannan
MT: Is therapy with embryonic microenvironment alternative to cytotoxic therapy in cancer?
Answer: Also with regenerative morphogenic microenvironment, f.ex. cartilagineous fracture callus (as found by J. Erenpreiss in 60-ths). I think that a morphogenic field may be important. Cytotoxic therapy is hopeless.
Are morphogenic fields bioenergetic states or determined by chemotaxis or both?
Morphogenic fields are the subject of embryonal inducer (organisers) gradients (Spemann, Nobel Prize 1935) but twiggs always include bi-potential cells. Leo Wolpert developed the theory of morphogenic fields (1969) composed of activation centres and elementary units, which specify this information. I do treat this as a bioenergetic field and think that this theory is very important. Leo is still alive. Alexander Gurwich developed in 1912-40 ths the theory of the biological (mitogenic) field based on weak photon irradiation which he registered (in cancer cells, by the way, too and dreamt to cure cancer). The developers are his grandson Lev Belousov (see on ResearchGate) and more internationally Fritz-Albert Popp, who organised an International Institute of Biophysics in Neuss (1996), a deep researcher. I have his book Electromagnetic bio-information (1981), it has likely already 4th edition in 2016. You can find his interview and lectures https://www.youtube.com/watch?v=R30YKfEuyo0
F-A Popp wrote together with Walter Nagl in 1983-ths a couple of articles on the elecromagnetic theory of differentiation, they referred to Gurwich. Nagl W and F.A. Popp A. physical (electromagnetic) theory of differentiation. I Basic considerations.
Cytobios 1983, 37:45-62.
Is nichotherapy appropriate name ?
Nichotherapy for stem cells: There goes the neighborhood
Jean-Pierre Levesque,
Ingrid G. Winkler,
John E. J. Rasko
DOI: 10.1002/bies.201200111
Abstract
Stem cells and their malignant counterparts require the support of a specific microenvironment or “niche”. While various anti-cancer therapies have been broadly successful, there are growing opportunities to target the environment in which these cells reside to further improve therapeutic efficacy and outcome. This is particularly true when the aim is to target normal or malignant stem cells. The field aiming to target or use the niches that harbor, protect, and support stem cells could be designated as “nichotherapy”. In this essay, we provide a few examples of nichotherapies. Some have been employed for decades, such as hematopoietic stem cell mobilization, whereas others are emerging, such as chemosensitization of leukemia stem cells by targeting their niche.
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