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Theoretically, the Quorum Sensing (QS) mechanism may be disrupted by any condition which prevents a faithful "count" of SC neighbors. This can be either due to reduced sensitivity of the SC itself, e.g., shortage of adequate receptors for environmental signals, or due to reduced "clarity" in the environment, concealing extracellular signals from the SC. The result in both cases is weakened ability to sense the "true" number of SCs in the micro-environment and, as a consequence, incessant proliferation and elusion of normal homeostatic tissue control. These two properties can be integrated into one parameter, the magnitude of intercellular communication sensed by a SC, which is expected to be the critical determinant of the tissue's steady-state production of end cells.
Agur Z, Kogan Y, Levi L, et al. Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells. Biology Direct. 2010;5:20. doi:10.1186/1745-6150-5-20.
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Kindly look at links here
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874533/
Article Peptides as Quorum Sensing Molecules: Measurement Techniques...
http://dspace-roma3.caspur.it/bitstream/2307/3930/1/Quorum%20sensing%20and%20pyoverdine%20signaling%20possible%20targets%20for%20the%20development%20of%20inhibitors%20of%20P.a.pdf
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Trosko JE. J Cancer Treat & Diagnosis. (2017); 2(1): 26-30 Journal of Cancer Treatment and Diagnosis
Commentary: How Evolution of Quorum Sensing Must Fit into the Understanding of The Origin, Prevention and Treatment of cancer
James E. Trosko Department of Pediatrics and Human Development College of Human Medicine Michigan State University East Lansing, USA
http://www.cancertreatmentjournal.com/articles/commentary--how-evolution-of-quorum-sensing-must-fit-into-the-understanding-of-the-origin-prevention-and-treatment-of-cancer.pdf
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