03 March 2018 4 10K Report


Theoretically, the Quorum Sensing (QS) mechanism may be disrupted by any condition which prevents a faithful "count" of SC neighbors. This can be either due to reduced sensitivity of the SC itself, e.g., shortage of adequate receptors for environmental signals, or due to reduced "clarity" in the environment, concealing extracellular signals from the SC. The result in both cases is weakened ability to sense the "true" number of SCs in the micro-environment and, as a consequence, incessant proliferation and elusion of normal homeostatic tissue control. These two properties can be integrated into one parameter, the magnitude of intercellular communication sensed by a SC, which is expected to be the critical determinant of the tissue's steady-state production of end cells.

Agur Z, Kogan Y, Levi L, et al. Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells. Biology Direct. 2010;5:20. doi:10.1186/1745-6150-5-20.

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