J Cell Sci. 2014 Feb 15;127(Pt 4):709-17. doi: 10.1242/jcs.140103.

The Hippo-YAP signaling pathway and contact inhibition of growth.

Gumbiner BM(1), Kim NG.

Author information:

(1)Department of Cell Biology, University of Virginia School of Medicine,

Charlottesville, VA 22908, USA.

The Hippo-YAP pathway mediates the control of cell proliferation by contact

inhibition as well as other attributes of the physical state of cells in tissues.

Several mechanisms sense the spatial and physical organization of cells, and

function through distinct upstream modules to stimulate Hippo-YAP signaling:

adherens junction or cadherin-catenin complexes, epithelial polarity and tight

junction complexes, the FAT-Dachsous morphogen pathway, as well as cell shape,

actomyosin or mechanotransduction. Soluble extracellular factors also regulate

Hippo pathway signaling, often inhibiting its activity. Indeed, the Hippo pathway

mediates a reciprocal relationship between contact inhibition and mitogenic

signaling. As a result, cells at the edges of a colony, a wound in a tissue or a

tumor are more sensitive to ambient levels of growth factors and more likely to

proliferate, migrate or differentiate through a YAP and/or TAZ-dependent process.

Thus, the Hippo-YAP pathway senses and responds to the physical organization of

cells in tissues and coordinates these physical cues with classic

growth-factor-mediated signaling pathways. This Commentary is focused on the

biological significance of Hippo-YAP signaling and how upstream regulatory

modules of the pathway interact to produce biological outcomes.

PMCID: PMC3924201 [Available on 2015/2/15]

PMID: 24532814 [PubMed - in process]

Int J Cancer. 2014 Jul 10. doi: 10.1002/ijc.29073. [Epub ahead of print]

Hippo-YAP signaling pathway: A new paradigm for cancer therapy.

Ma Y(1), Yang Y, Wang F, Wei Q, Qin H.

Author information:

(1)Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated with Tongji

University, Shanghai, People's Republic of China.

In the past decades, the Hippo signaling pathway has been delineated and shown to

play multiple roles in the control of organ size in both Drosophila and mammals.

In mammals, the Hippo pathway is a kinase cascade leading from Mst1/2 to YAP and

its paralog TAZ. Several studies have demonstrated that YAP/TAZ is a candidate

oncogene and that other members of the Hippo pathway are tumor suppressive genes.

The dysregulation of the Hippo pathway has been observed in a variety of cancers.

This review chronicles the recent progress in elucidating the function of Hippo

signaling in tumorigenesis and provide a rich source of potential targets for

cancer therapy.

© 2014 UICC.

PMID: 25042563 [PubMed - as supplied by publisher]

Close to you! Salut +

Thanks Dr. Gros, it is useful. But I am worried that  funds and time will be wasted due to a negative result. After all, it is not a hot topic such as EGFR pathway.