Resveratrol during pregnancy may cause abnormalities in the fetus, according to a new study done in primates called Japanese macaques. Although the study was conducted on animals, the researchers recommend that pregnant women should refrain from taking supplement of resveratrol
Another research from Oregon Health & Science University and the University of Colorado-Denver suggests that taking such supplements during pregnancy may cause pancreatic problems for the fetus.
All other animal studies show that Resveratrol is safe in pregnancy. USFDA classifies it as GRAS even in Pregnancy (small doses from dietary sources). This study in macaques is a bit disturbing, even though consequences of increased pancreatic mass are not clear.
Many other authors imply that it is a nutritional anti inflammatory and antioxidant, and therefore imply that it is safe. IUGR could be the only indication during pregnancy , where it's use may be warranted.
Just in case, if you come across any human trials in pregnancy please inform me.
I think it is important to point out that there are no standards for supplements. Therefore, when you buy and take a supplement, there is no way of knowing what is actually in the pill. So, as in the case of all supplements, there is no way of knowing if it has any resveratrol in it at all, and if yes, how much and if not, then what is in the pill. Therefore, in the case of Resveratrol, which are available in food such as red grapes and blueberries, it would be optimal to get what you need from food sources.
I think the best and quickest pregnancy nutritional advice, without taking a 3 hour individualized session, is one cup of chopped parseley per day of pregnancy and fish 3 times per week
Thank you very much. I had come across the study about increased pancreatic mass in macaques. Since Resveratrol activates Sirtuins, the change is likely to be as per our genetic design.
Would the increased pancreatic mass result in better digestion and almost no diabetes ? So far this possibility has not been studied.
Jian Ding et al, Endocrine Connections 2017, (6) had found it safe and effective (after 20 weeks of gestation) for co-prescription with Nifedipine.
in vitro findings on the sensitivity of human fetal adrenal steroidogenesis to resveratrol at GW9-12 suggest that intake of this polyphenol at high doses by women who are at early stages of pregnancy is undesirable.
results demonstrate that resveratrol use during pregnancy yields improvements in maternal and placental phenotype with beneficial effects in the fetal liver but an unexplained and concerning alteration in fetal pancreatic development, which strongly cautions against the use of resveratrol by pregnant women
Resveratrol does not appear to have side effects at short-term doses (1.0 g). Otherwise, at doses of 2.5 g or more per day, side effects may occurs, like nausea, vomiting, diarrhea and liver dysfunction in patients with non-alcoholic fatty liver disease
Since resveratrol is hailed for numerous benefits to health, it is no wonder supplements of the compound are popular. But new research from Oregon Health & Science University and the University of Colorado-Denver suggests that taking such supplements during pregnancy may cause pancreatic problems for the fetus. https://www.google.com/amp/s/www.medicalnewstoday.com/amp/articles/277738