Detection of actionable mutations are discovered in only 5% of malignant tumors. So, we need to find out more effective ways for detecting somatic action vulnerabilities in vitro for developing potential future strong effective anti-cancer agents.
Yes, but genomics is the first step only. Always remember, nature (genes and all mutations, inherited and acquired) and nurture (nutrition, especially microbiota, life style, the stress) go together, almost equally important. You reach precision when you can control both. Also, the acquired somatic mutations are random, not all of them can be relevant to cancer and we don’t always know (yet!) their significance.
No, Pure genomics is not a solution for anything. We have to consider that proteins are a product of genes and eventually metabolites. Thus, without considering the translation and metabolism related ti genes, the genomics is kind of lame. Mutation always happens, but how would we know what is the effect of that mutation? Does this has any big impact on transcriptome, proteome or metabolome?
In genomics you not only look at mutations at DNA level but also can analyze and identify many post transcriptional modifications including thousands of sites edited at RNA level and variation in alternate splicing which are found to be associated with cancer
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