Hello,
I was wondering about your opinon on addition of LPS to caerulin in provoking acute pancreatitis (model of repeated caerulin i.p. injection followed by dose of LPS to exacerbate pancreatiis).
As acute pancreatitis is basically a state of sterile inflammation, what is the justification for using such a model?
Hello, you can use MSU (monosodium urate) crystals for such a model. I think LPS is more used for induction of sepsis.
Hi Iskander, nice that you replied!
I get it that LPS is more used for models of sepsis, and for me it could be used to mimic the late phase of severe acute pancreatitis (as infection of fluid collections appear in clinical late phase of acute pancreatitis).
However, I try to understand why some authors use this for studying acute pancreatitis:
Article A mouse model of severe acute pancreatitis induced with caer...
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