Dear Dalia,
The following links contain recent publications on aquaporins immunohistochemistry in Egypt:
1- G Ital Dermatol Venereol. 2016 Feb 29. [Epub ahead of print]
Immunohistochemical expression of Aquaporin-3 protein in vitiligo; a new potential guide for disease activity.
Hodeib A1, Hegab D, Rizk O, Mohammed S.
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Abstract
BACKGROUND:
Vitiligo is a depigmenting skin disorder, with disappearance of functioning epidermal melanocytes. Aquaporin-3 (AQP-3) is an aquaglyceroporin expressed in epidermal keratinocytes, where it shares in regulating their proliferation and differentiation, and so it might affect melanocytes indirectly. So far, little is known regarding its possible role in vitiligo.
AIM:
This work aimed to study the changes in immunohistochemical expression of AQP-3 protein in vitiligo to detect its possible role in disease pathogenesis.
METHODS:
Skin biopsies were taken from lesional skin of 30 vitiligo patients in addition to 20 normal controls. Epidermal immunohistochemical expression of AQP-3 was assessed as: +3 = strong expression, +2 = moderate, +1= weak and 0= negative expression.
RESULTS:
AQP-3 was significantly less expressed in vitiligo epidermis than control (P
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