In NMR is H,C COSY the same as HSQC?

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Shalini Pandey

As COSY is basically correlated spectroscopy, in many older texts HSQC has been mentioned as H, C COSY. Both HETCOR and HSQC show H and C correlation but the basic difference is that in HECTOR proton is in an indirect dimension while in HSQC carbon is in the indirect dimension. Also, HSQC is more sensitive due to the INEPT sequence.

Eduardo Miguez

For interpretation purposes there is no difference. The difference is in the acquisition process. Depending on the device and software used in spectra processing(MestreNova) , in HSQC it is possible to distinguish the CH2 carbons. Important to highlight that both H-C cosy or HSQC, the observed correlation is C-H.