If there are two different proteins being evaluated for diagnostic potential, how do you calculate sensitivity and specificity?

Marcia Moss @Marcia-Moss

04 December 2013 1 9K Report

If both together, give better prognostic value, than either alone, how do you determine this mathematically?

Karoly Szuhai

Hello,

Try this article as a starting point:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636062/

Good luck!

Karoly

Badges
Science method

More Marcia Moss's questions See All

Can I use carbo-free blocking solution in place of normal goat serum?

I'm looking to try this in place of normal goat serum for a wisteria floribunda lectin stain. In my IF protocol, 10% of the final volume of my blocking solution is goat serum. If I were to go the...

07 February 2021 7,520 6 View

Can problems with blocking cause high background and weak antibody signal during immunofluorescence staining?

I'm working with 40um fresh frozen (non-perfused) sections of rat brain tissue and I'm staining for wisteria lection (immunofluorescence). After staining, my tissue has high background and a weak...

10 November 2020 3,620 7 View

Does anyone work with femoral and tibia radiography on rats or mices?

I would like to know what protocol followed for animals undergoing some treatment that induces some type of osteopenia / loss of bone density.

13 July 2019 1,731 2 View

What are the best research-based tools to teach pronunciation of L2 segments to second language learners?

Last year I attended an International Conference at the University of Utah about the teaching of pronunciation in second language learning and teaching. I notice that there was a general...

23 May 2018 5,599 2 View

Will thrombin aptamers bind immobilized/denatured thrombin?

I'm interested in modifying a polyacrylamide gel-based immunoassay to use aptamers in place of antibodies. In this assay, the proteins are covalently immobilized within the polyacrylamide gel via...

15 May 2018 5,490 2 View

How is your research likely to improve the approach to measuring performance quality?

I would be very interested in reading your publications related to measuring health and safety/ quality/ operations management performance - especially those related to recommendations for...

17 February 2017 7,501 2 View

Statistical Data: Experimental Design (teaching, how many students, control and normal group, definite conclusions)?

An innovative proposal, so say a new way of presenting contents or a small book with innovative ways of creating reasoning patterns: What do I need to have to prove to others, in a fully...

30 May 2016 9,386 3 View

Can you suggest a good assay to determine paracellular permeability in epithelial cells?

I am establishing a bovine oviductal epithelial cells culture using inserts of 0.4um pores and I am trying to get the cells polarized with this system. I would like to use the permeability assay...

16 January 2014 7,820 18 View

What is the role of the cerebellum in emotional processing and behavior?

Aims Neuroscience is requesting paper submissions for our April issue. Manuscripts will need to be received by February 28, 2014, and decisions on acceptance will be completed by March 28. Some...

19 December 2013 6,839 5 View

Is brain circuitry or brain chemicals the level that best explains psychopathology, including depression and schizophrenia?

The view that a chemical imbalance is the key to understanding and treating psychopathology has been dominant for years, but brain circuitry has become more popular as an explanation the past few...

01 December 2013 9,019 8 View

How to code open-ended questions in SPSS?

Hello all, In SPSS I am going to code 2 open-ended questions. I have already read all the answers and I made a list of the most important categories to which I can code the answers. This question...

02 March 2021 1,757 4 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

How to eliminate Steady state error from Reinforcement learning genetic algorithm code?

The following code (see 1st 2 images attached) is used to produce PID controller values that are designed to control the system (G). The code finds the PID controller values (noted as k) by using...

28 February 2021 6,560 14 View

How could I process data in RCT to include it in meta-analysis?

I'm in the process of doing a meta-analysis and have encountered some problems with the RCT data. One of my outcom is muscle strength. In one study, I have three different measurements of muscle...

25 February 2021 7,603 3 View

Satellite orbit estimation using Recurrent Neural Network - what should I use?

Hello, I am a master's student studying in Yonsei Univeristy, Korea. I am trying to estimate the state of satellite, using Neural Network. Below is a simple flow of my study. 1. Train (t0 ~ t1)...

23 February 2021 6,383 3 View

Is it possible that Cancer cells could survive in heparinized blood for 48 hours?

Hi everyone, I am just wondering if we incubated 200 microliter of whole blood with 50 microliter of cancer cells(1bout 5000cells) do you think that cancer would survive for 48 hours?

23 February 2021 3,840 3 View

Any Differences in COVID-19 vaccines?

Are there any differences (outside of the clinical trials that led to their EUA) observed in the rate of infection among those who have received the Pfizer vs Moderna vaccine since the mass...

22 February 2021 9,727 6 View