Dear Athar

Yes, If drug loaded microspheres are compressed into tablet then compression will affect the drug release pattern so I will suggest you that if you want to check the drug release pattern of your microspheres encapsulated with the drug then use Dialysis Tube Method to check drug release pattern. Because in dialysis tube method, it is not necessary to make a tablet of drug loaded microspheres to check drug release pattern

If you have more question then I will be happy to answer it.

Cheers

Dear Muhammad Usman Munir

I want to check separate release pattern of each and want to study that either compression effected on sustain or controlled behaviour of  encapsulated microspheres or not.

Ok.

So you should follow 2 steps;

1. Check the release study through dialysis tube method without compressing drug loaded microspheres and note the results.

2. Compress microspheres encapsulated with drug and check the drug release pattern. Note the results and compare with the first one.

NOTE: Don't use any diluent or binder when you are going to compress the drug loaded microsphere because these substances can also affect drug release pattern in addition to compression action.

Compression into tablet will not be a problem if tablet disintegrates immediately (less than 15 min) which is usually the case.

Yes , agreed with Dr. Mubashar Rehman

But as stated in the comment, I think Athar wants to do the study that either compression does affect on drug release study or not. Otherwise, if disintegration time is not disturbed by compression then ALL IS WELL.

Compression will not affect the dissolution and disintegration pattern of a oral preparation if a tablet is composed of drug-loaded microspheres. Instead a slow and pulsatile release follows if it is a transdermal therapeutic system (TDS).

In addition to all these, don't forget to do check compatibility of microparticles and tablet excepients because any interaction will impact drug release.

Exactly I do agree with the various excipients used and usually posess hindrance to PK of the drug.

Well this is a very good question.  On the one hand, higher compression force increases the density and hardness of tablet, decreases porosity and hence penetrability of the solvent into the tablet, retards wettability by forming a firmer and more effective sealing layer by the lubricant and in many cases promotes tighter bonding between the particles all of which result in slowing of the dissolution rate of the tablets.  On the other hand, higher compression force causes deformation, crushing or fracture of coating and drug particles as well or convert microspheres into disc shaped particles with a large exposure of drugs, which in turn increases the effective surface area of the drug. This results in an increase in dissolution rate of the tablet. Hope I answered your question. Many thanks

yes

it will affect the drug release.it also depends upon which type of excipient you have added and also on your micro spheres  release.

Good Morning, yes the drug release pattern changes due to the compression load exerted on the microspheres the more load you apply on the microspheres more harder the tablet will be and the release pattern changes, also the effect of surface area changes the drug release pattern, microspheres has larger surface area compared to tablet, as smaller the particles larger the surface area.

Hence there is change in the drug release.

hope i answer the question.

Yes it will effect the release. However you could add a disolvent to the DC tablet to speed the process along, please check if this will have an effect on the microspheres