I am currently studying the db/db K strain and have a project with updates regarding my transmission electron microscopic findings
and I have found that in this obese insulin resistant model with persistent elevations of glucose making it a definite type 2 DM model that has preexisting obesity and insulin resistance that the astrocyte
become separated from the NVU Endothelial basement membrane and become retracted as well. These TEM finding obliterate the normal astrocyte corona as found in control models regarding studies of the NVU (neurovascular unit). Do you think these findings are compatible with impaired signaling of the other NVU in the midbrain cortex as in my project findings.
Sincerely,
M. R. (Pete) Hayden, MD
[email protected] - if you would prefer to answer by e-mail correspondence.
Dr. Hyden, this is a very recent multidisciplinary project, we are working on the identification of the components of the sample through chromatography, spectrometry and magnetic resonance. We are starting studies in the hyperglycemic mouse with a skin lesion that includes the destruction of the epidermis and deep dermis. We intend to evaluate the regenerative activity of the skin layers, vascularization, etc., in these animals treated with the substance. We do not have publications so far and we are looking for financing to continue advancing in the coming years. So we keep in communication by RG or email ([email protected])
Sincerely,
Rolando García
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