Recently, I was introduced to perivascular spaces (PVS) while studying lipopolysaccharide treated models with transmission electron microscopy (TEM).
Erickson MA, Shulyatnikova T, Banks WA, Hayden MR. Ultrastructural Remodeling of the Blood-Brain Barrier and Neurovascular Unit by Lipopolysaccharide-Induced Neuroinflammation. Int J Mol Sci. 2023; 23(24(2). DOI:10.3390/ijms24021640
PVS fascinates and intrigue me. I know that they are normally present in post-capillary venules and that they are a biomarker for small vessel disease (SVD) they are enlarged (EPVS) and EPVS are increased in aging.
I look forward to any input and suggestions for me as I will soon begin studying very old CD-a mice brains and I am in hopes to find some new knowledge regarding EPVS with the use of TEM.
Please make suggestions and submit any papers that you feel might be important in this future study.
Melvin R Hayden
University of Missouri School of Medicine
TEM core at the NexGen Precision Health Research Center
Columbia, Missouri USA
I think you might find this relevant to your research.
Article Responses of perivascular macrophages to circulating lipopol...
Milad,
Thank you for this information and I think that resident macrophages are playing a greater role than we have realized. In my previous study I only examined the cortex layer III so did not have the opportunity to examine the subfornical organs. Maybe in future studies of older models upcoming I can do this.
This was a great help and thank you so much.
I do not know specifically how to help others with my upcoming studies and this is one reason that I posted this question.
Melvin R Hayden
Your work in epigenetics sounds very interesting!
I have had interest in impaired folate one-carbon metabolism and how it affects the nuclear remodeling and nuclear chromatin condensation
Today I assembled some of my findings in regards to"
"Why are PVS important?"
I have just recently created a special series issue entitled:
Why are Enlarged Perivascular Spaces Important?
I would like to invite any and all to submit an unpublished manuscript to this
issue. It can be a review or present recent data regarding Enlarged Perivascular Spaces.
With Gratitude,
Melvin R. Hayden MD Guest Editor
University of Missouri School of Medicine
Columbia, Missouri USA
The first manuscript in the special series isssue:
Why are Enlarged Perivascular Spaces Important? was published today 10 May 2023 in Medicina Series Issue at the following address.
https://www.mdpi.com/1648-9144/59/5/917
It is hoped that this paper published by Tatyana Shulyatnikova will help to increase the interest in this topic of Enlarged Perivascular spaces. She has included TEM images and descriptive illustrations to empower the reader with greater knowledge regarding why Perivascular Spaces are important.
We hope that more people will become interested and share their thoughts and their findings not only in this open discussion but that they will also consider submitting some of their recent novel findings regarding Enlarged Perivascular spaces at the following address or link as follows:
https://www.mdpi.com/1648-9144/59/5/917
Please see my new Preprint from Preprints.org regarding:
Brain endothelial cells play a central role in the development of enlarged perivascular spaces in the metabolic syndrome. Preprints.org 2023 May 19
https://www.preprints.org/manuscript/202305.1406/v1
The paper also appears in my research section as a PDF preprint.
Hayden, M.R. Brain Endothelial Cells Play a Central Role in the Development of Enlarged Perivascular Spaces in the Metabolic Syndrome. Preprints.org 2023, 2023051406. https://doi.org/10.20944/preprints202305.1406.v1.
Melvin R Hayden
University of Missouri School of Medicine
Columbia, Missouri
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