Melvin Hayden

12 Questions 43 Answers 0 Followers

Questions related from Melvin Hayden

Why are perivascular space important?

Recently, I was introduced to perivascular spaces (PVS) while studying lipopolysaccharide treated models with transmission electron microscopy (TEM). Erickson MA, Shulyatnikova T, Banks WA,...

17 February 2023 2,446 7 View

Do you have any thoughts regarding the importance of folate-mediated one--carbon metabolism in COVID 19?

Soon I will be writing a paper on IMPAIRED Folate-mediated One-Carbon Metabolism (FOCM) in COVID-19, and I will be needing input from a vast array of scientists and researchers who are interested...

26 September 2021 4,478 3 View

SARS-CoV-2 Viremia: How do pulmonary infections advance to extrapulmonary manifestations in COVID-19?

The process of viremia involving the transfer of the whole virus from pulmonary alveolar epithelial pneumocytes to the alveolar capillaries and hence to the systemic circulation is not well...

08 October 2020 890 6 View

Could ACE2 in adipose tissue visceral depots contribute to the immediate as well as the long-term complications of SARS-CoV-2 binding and COVID-19?

We have known for some time that the visceral adipose tissue plays an important role regarding the metabolic syndrome and type2 diabetes mellitus (T2DM); however, the finding that ACE2 staining is...

09 August 2020 6,582 4 View

Will Type 2 diabetes mellitus be late complications of COVID-19 SARS-CoV-2 infections?

Indeed, there is a bidirectional relationship between Covid-19 and diabetes and since my interests have always been in the field of MetS and type 2 diabetes mellitus (T2DM) I pose this question...

26 June 2020 2,360 5 View

Why are males a greater risk for developing COVID-19 morbidity and mortality across a wide range of age spectrums?

It is becoming more and more clear that males are at a greater risk of developing infections with COVID-19 and are at a greater risk of morbidity and mortality. This is open to thoughts...

22 March 2020 3,929 8 View

Recommendations for use of specific stains with normal TEM fixative to enable one to study the the thoracic aorta endothelial glycocalyx?

We wish to see if the endothelial glycocalyx is decreased in diabetic models and excess sodium models and we wanted to know if anyone had any suggestions for additive stains to standard TEM...

28 May 2018 3,345 5 View

Significance of Insulin being sytesized and secreated in the brain

I recently found out that Mazucanti CH et al had discovered that insulin was synthesized in the choroid plexus within ependymal cells of the brain. I was very excited to learn this as a source...

01 January 1970 9,733 6 View

Are asymmetrical synaptic excitatory junctions increased in the diabetic brain ?

I have noticed an increased in the asymmetrical synaptic excitatory junctions to be increased in the diabetic brain but could not find any discussion of this in the literature at present. If you...

01 January 1970 4,080 5 View

Are Uric acid and lactic acid in COVID-19 increased?

Because the endothelial glycocalyx may be attenuated and or lost due to multiple metabolic toxicities in the intersection between Type 2 Diabetes and Met S in COVID-19 and the endothelial...

01 January 1970 6,903 3 View

Is sodium transport in red blood cells important in COVID-19 pandemic ?

The red blood cells contain a full complement of sodium transporters and cotransporters and since the RBC plasma membranes were utilized initially in the early studies of sodium transport, I am...

01 January 1970 6,937 9 View

What are some of your thoughts and concepts regarding the role of peripherally derived extracellular vesicle exosomes and miRNAs?

Dear friends and colleagues, I have recently found definite extracellular nanometer vesicles (60-70nm in diameter) being extruded from rupture-prone adipocytes and crown-like structure...

01 January 1970 5,200 0 View