How would expression of a gene targeted by thyroid hormone be affected by deletion of thyroid hormone receptor in the absence of hormone? How about in thyroid hormone-treated cells? Please, elaborate your answers.
Let it be the hormone thyroxine. On the surface of thyrocytes there is a receptor for thyroxine, encoded by a gene. If there is a deletion of the TSH receptor, then the gene will be overexpressed to maintain equilibrium.
Although I have a patient with a genetic disorder who is not sensitive to thyroxine in the absence of a thyroid gland.