We published a paper about a biomarker we extracted from patients sample, did PCR, found its expression. Now, we did bioinformatic using software which search the mechanisms of this marker. When writing methodology of the newer paper, shall I write that in the present study we tested x patients? Or say in previous study we tested x patients and limit methodology to bioinformatics? In this case, what the type of the new study based on this bioinformatics finding? I don't think RCT anymore. But don't know what would be
It is good to refer the previous paper for the same methodology used in the present study.
Hi,
One key evaluation of papers regarding to methodology is sensitivity and specificity or parameters for accuracy. It is very important to define the gold standard. Your previous findings could do this.
I suggested you put some public data, from SRA or elsewhere, in the new paper. Therefore,
"bioinformatics -> find out something -> validate by previous data (gold standard) -> general validated by public data or other latest in-house data"
It is a good way to cite your previous publications for the same parts such as:
"...The disease risk score (DRS) method [21] was applied to the resulting minimal multitranscript signature to translate it into a single value that could be assigned to each...."
It is the most important to make sure audiences can understand your logic and "Do not re-invent wheels".
Cheers,
Yang
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